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cb2 receptor antagonist am630  (MedChemExpress)


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    MedChemExpress cb2 receptor antagonist am630
    Cb2 Receptor Antagonist Am630, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 13 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/cb2+receptor+antagonist+am630/6-Iodopravadoline/pm34774714-47-5-22
    Average 93 stars, based on 13 article reviews
    cb2 receptor antagonist am630 - by Bioz Stars, 2026-10
    93/100 stars

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    Article Title: Cannabinoid Receptor Type 2 Agonist Reduces Morphine Tolerance via Mitogen Activated Protein Kinase Phosphatase Induction and Mitogen Activated Protein Kinase Dephosphorylation.
    Article Snippet: Morphine is an opioid drug often used in treating moderate to severe pain.. However, morphine tolerance in patients limits its used in clinical settings.. Our previous study showed that a cannabinoid type 2 (CB2) receptor agonist attenuated morphine tolerance.



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    Figure 6. BDNF blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 7) or 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 7), 1 mg/kg <t>AM630</t> + 5 mg/kg CBDA-ME (n = 7). * p < 0.05.
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    ( A ) Duration of immobility of female WKY rats ( B ) duration of swimming (mean + SEM) of female WKY rats. Rats received either vehicle (n = 13) or 5 mg/kg CBDA-ME (n = 13), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 12), 1 mg/kg <t>AM630</t> + 5 mg/kg CBDA-ME (n = 12), 30 mg/kg Imipramine (n = 12). * p < 0.05.
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    ( A ) Duration of immobility of female WKY rats ( B ) duration of swimming (mean + SEM) of female WKY rats. Rats received either vehicle (n = 13) or 5 mg/kg CBDA-ME (n = 13), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 12), 1 mg/kg <t>AM630</t> + 5 mg/kg CBDA-ME (n = 12), 30 mg/kg Imipramine (n = 12). * p < 0.05.
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    Figure 6. BDNF blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 7) or 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 7). * p < 0.05.

    Journal: International journal of molecular sciences

    Article Title: Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats.

    doi: 10.3390/ijms24043828

    Figure Lengend Snippet: Figure 6. BDNF blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 7) or 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 7). * p < 0.05.

    Article Snippet: Experiment 2: A selective CB1 receptor antagonist AM251 (1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)4-methyl-N-(1-piperidinyl)-1H pyrazole-3 carboxamide; Tocris Bioscience, UK) and a selective CB2 receptor antagonist AM630 (6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol3-yl](4methoxyphenyl) methanone; Tocris, Bristol, UK) were initially dissolved in dimethyl sulphoxide (DMSO; SIGMA, St. Louis, MO, USA) and then diluted with 0.9% saline using TWEEN 80 (SIGMA, St. Louis, MO, USA).

    Techniques:

    Figure 7. Selected endocannabinoids blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 4) or 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 5). * p < 0.05; ** p< 0.01.

    Journal: International journal of molecular sciences

    Article Title: Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats.

    doi: 10.3390/ijms24043828

    Figure Lengend Snippet: Figure 7. Selected endocannabinoids blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 4) or 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 5). * p < 0.05; ** p< 0.01.

    Article Snippet: Experiment 2: A selective CB1 receptor antagonist AM251 (1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)4-methyl-N-(1-piperidinyl)-1H pyrazole-3 carboxamide; Tocris Bioscience, UK) and a selective CB2 receptor antagonist AM630 (6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol3-yl](4methoxyphenyl) methanone; Tocris, Bristol, UK) were initially dissolved in dimethyl sulphoxide (DMSO; SIGMA, St. Louis, MO, USA) and then diluted with 0.9% saline using TWEEN 80 (SIGMA, St. Louis, MO, USA).

    Techniques:

    Figure 8. FAAH expression in the hippocampus (mean + SEM) of female WKY rats. Rats received either vehicle (n = 4) or 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 5). * p < 0.05, ** p< 0.01.

    Journal: International journal of molecular sciences

    Article Title: Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats.

    doi: 10.3390/ijms24043828

    Figure Lengend Snippet: Figure 8. FAAH expression in the hippocampus (mean + SEM) of female WKY rats. Rats received either vehicle (n = 4) or 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 5). * p < 0.05, ** p< 0.01.

    Article Snippet: Experiment 2: A selective CB1 receptor antagonist AM251 (1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)4-methyl-N-(1-piperidinyl)-1H pyrazole-3 carboxamide; Tocris Bioscience, UK) and a selective CB2 receptor antagonist AM630 (6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol3-yl](4methoxyphenyl) methanone; Tocris, Bristol, UK) were initially dissolved in dimethyl sulphoxide (DMSO; SIGMA, St. Louis, MO, USA) and then diluted with 0.9% saline using TWEEN 80 (SIGMA, St. Louis, MO, USA).

    Techniques: Expressing

    ( A ) Duration of immobility of female WKY rats ( B ) duration of swimming (mean + SEM) of female WKY rats. Rats received either vehicle (n = 13) or 5 mg/kg CBDA-ME (n = 13), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 12), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 12), 30 mg/kg Imipramine (n = 12). * p < 0.05.

    Journal: International Journal of Molecular Sciences

    Article Title: Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats

    doi: 10.3390/ijms24043828

    Figure Lengend Snippet: ( A ) Duration of immobility of female WKY rats ( B ) duration of swimming (mean + SEM) of female WKY rats. Rats received either vehicle (n = 13) or 5 mg/kg CBDA-ME (n = 13), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 12), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 12), 30 mg/kg Imipramine (n = 12). * p < 0.05.

    Article Snippet: Experiment 2: A selective CB1 receptor antagonist AM251 (1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)- 4-methyl-N-(1-piperidinyl)-1H pyrazole-3 carboxamide; Tocris Bioscience, UK) and a selective CB2 receptor antagonist AM630 (6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4methoxyphenyl) methanone; Tocris, Bristol, UK) were initially dissolved in dimethyl sulphoxide (DMSO; SIGMA, St. Louis, MO, USA) and then diluted with 0.9% saline using TWEEN 80 (SIGMA, St. Louis, MO, USA).

    Techniques:

    BDNF blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 7) or 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 7). * p < 0.05.

    Journal: International Journal of Molecular Sciences

    Article Title: Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats

    doi: 10.3390/ijms24043828

    Figure Lengend Snippet: BDNF blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 7) or 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 7). * p < 0.05.

    Article Snippet: Experiment 2: A selective CB1 receptor antagonist AM251 (1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)- 4-methyl-N-(1-piperidinyl)-1H pyrazole-3 carboxamide; Tocris Bioscience, UK) and a selective CB2 receptor antagonist AM630 (6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4methoxyphenyl) methanone; Tocris, Bristol, UK) were initially dissolved in dimethyl sulphoxide (DMSO; SIGMA, St. Louis, MO, USA) and then diluted with 0.9% saline using TWEEN 80 (SIGMA, St. Louis, MO, USA).

    Techniques:

    Selected endocannabinoids blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 4) or 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 5). * p < 0.05; ** p < 0.01.

    Journal: International Journal of Molecular Sciences

    Article Title: Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats

    doi: 10.3390/ijms24043828

    Figure Lengend Snippet: Selected endocannabinoids blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 4) or 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 5). * p < 0.05; ** p < 0.01.

    Article Snippet: Experiment 2: A selective CB1 receptor antagonist AM251 (1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)- 4-methyl-N-(1-piperidinyl)-1H pyrazole-3 carboxamide; Tocris Bioscience, UK) and a selective CB2 receptor antagonist AM630 (6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4methoxyphenyl) methanone; Tocris, Bristol, UK) were initially dissolved in dimethyl sulphoxide (DMSO; SIGMA, St. Louis, MO, USA) and then diluted with 0.9% saline using TWEEN 80 (SIGMA, St. Louis, MO, USA).

    Techniques:

    FAAH expression in the hippocampus (mean + SEM) of female WKY rats. Rats received either vehicle (n = 4) or 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 5). * p < 0.05, ** p < 0.01.

    Journal: International Journal of Molecular Sciences

    Article Title: Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats

    doi: 10.3390/ijms24043828

    Figure Lengend Snippet: FAAH expression in the hippocampus (mean + SEM) of female WKY rats. Rats received either vehicle (n = 4) or 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 5). * p < 0.05, ** p < 0.01.

    Article Snippet: Experiment 2: A selective CB1 receptor antagonist AM251 (1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)- 4-methyl-N-(1-piperidinyl)-1H pyrazole-3 carboxamide; Tocris Bioscience, UK) and a selective CB2 receptor antagonist AM630 (6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4methoxyphenyl) methanone; Tocris, Bristol, UK) were initially dissolved in dimethyl sulphoxide (DMSO; SIGMA, St. Louis, MO, USA) and then diluted with 0.9% saline using TWEEN 80 (SIGMA, St. Louis, MO, USA).

    Techniques: Expressing